|
KMID : 0043319990220030306
|
|
Archives of Pharmacal Research
1999 Volume.22 No. 3 p.306 ~ p.308
|
|
|
Enzymatic Synthesis of a Dihydrobenzofuran Neolignan by Oxidative Coupling
|
|
Yeo Ho-Sup
Lee Jou-Heon
Kim Jin-Woong
|
|
|
Abstract
|
|
|
|
The oxidative dimerization of ferulic acid has been carried out using horse-radish peroxidase as catalyst to give a dihydrobenzofuran neolignan (1), the structure of which was elucidated as (2SR, 3RS)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3n-butoxycarbonyl-5-(2E-carboxyethenyl)-7methoxybenzofuran by spectroscopic analyses. This compound showed more potent cytotoxicity against several tumor cell lines than the starting material.
|
|
|
KEYWORD
|
|
|
Oxidative dimerization, Peroxidase, Ferulic acid, Dihydrobenzofuran neolignan, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|